It's extremely annoying when people post asking for help, but they've only posted "It crashes". Please, if you're asking for help then be as thorough as you can so we can help diagnose your problem as quickly as possible.
Things you should post when asking for help:
Hardware
If you don't know how to find out any of the information below then just go to start>search>dxdiag and hit enter (Windows 7 and Vista). If you're running Windows XP go to start>run>dxdiag.exe and hit enter. Show/Tell us what it says on the screen that opens, on both the system and display tabs.
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CPU.
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It's important to mention what make/model as well as how many GHz it runs at, as well as how many cores it has.
Graphics card.
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Please make sure to tell us what model your video card is, whether it be an onboard chipset or a GTX295.
RAM.
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Be as specific as you can when posting information about your RAM, try and state how many MB/GB and whether it's SD/DDR/DDR2/DDR3.
Operating system.
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Please mention which operating system you're using, whether it's Windows XP or Windows 7, etc. It's also important to mention whether you're using x86 (32bit) or x64 (64bit) operating system.
Emulation
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Which emulator you're using.
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There are lots of emulators out there, please try and be as specific as possible.
Which version of the emulator you're using.
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There are usually lots of versions of an emulator, so please be specific as to which version you're using.
Which plugins you're using.
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Please post your plugin configurations along with this information.
Have you tried an alternative ISO/ROM of the same game?
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It's possible it was a corrupt download or a bad copy of the game, it's always worth re-downloading another copy before asking for help if possible.
Or have you tried any other emulators?
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Some emulators have better compatibility than others, it's always worth trying another emulator or at least checking a compatibility list for the emulator you're using before asking for help.